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In addition protivoprotozoynogo of these drugs have protivovos-palitelny effect (the actuated is not clear). Leflunomide, inhibits дигидрооротатдегидрогеназу violates the synthesis of pyrimidine-DIN, and thus reduces the proliferation of ThC D4 + lymphocytes activated in rheumatoid arthritis. In acting on the body antigens Growth Hormone the system of humoral immuno-niteta and produced antibodies of class E, which fixed on the mast cells actuated . Gout uric acid crystals deposited in the synovial tissue. Significant improvement occurs within 4-5 months. Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes and neutrophils in the inflammatory and also actuated the ability of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. In rheumatoid arthritis Dpenitsillamin with systematic assignment inside a pronounced therapeutic effect after 3-4 months of treatment. Sulfasalazine - combined drug 5aminosalitsilovoy acid and sulfapiridina. Etanercept - a comprehensive drug fragments of recombinant TNF receptor and human IgG. These tools cause serious side effects, due to which about 1 / 3 of patients discontinue treatment prematurely. Blocks the receptors and TNF thus preventing the action of TNF. To prevent attacks of gout allopurinol use, which violates the synthesis of uric acid, and urikozuricheskoe tool sulfinpyrazone (anturan), which promotes the excretion of uric acid (violates the reabsorption of uric Transfer in renal tubules). For systemic use of prednisone, dexamethasone, triamtsino Lawn. In acute attacks of gout, these drugs are not recommended as they may initially exacerbate gout. 4Aminohinoliny actuated chloroquine (hingamin, delagil) and hydroxychloroquine (Plac-venil) - antimalarials. A characteristic pathological feature of the genetic disease is increasing levels of interleykina1 (IL1) and opuholeyalfa necrosis factor (TNF). To reduce the pain associated with acute attacks of gout are also used NSAIDs (diclofenac, ibuprofen), which in this case exert nonspecific anti-inflammatory and analgesic action-condition. In connection with the ability to bind Cu applied in Wilson's disease (hepatolenticular degeneration). In bronchial asthma used inhaled preparations of glucocorticoids, which are relatively little absorbed in the lungs and mainly have local anti-inflammatory effect - beclomethasone, budesonide, fluticasone, fluorescence-nizolid. NSAIDs with a systematic application even accelerate the development of rheumatoid arthritis (depress product-tion of prostaglandins E and 12, which reduces the Education IL1). In patients with rheumatoid arthritis at regular ingestion of these drugs are beginning to have a therapeutic effect about 1 month. The mechanism of action here unclear. In addition, glucocorticoids reduce the formation of the gene responsible for synthesis TSOG2. Using the drug reduced the level of gold rheumatoid factor (IgM). At the actuated in their application may be nausea, headache, visual disturbances (retinopathy), proteinuria, dermatitis. The mechanism of their antiinflammatory actions related to stimulation of expression of the gene responsible for the formation of lipokortina1, co-tory reduces the activity of phospholipase A2. In rheumatoid arthritis are also used cytostatic agent from the group antimetabo-lits - methotrexate. Specific "marker" of disease considered an autoimmune antibody IgM (rheumatoid factor). Applied also as Interthecal antidote for poisoning by compounds of Hg, Pb. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. The main side-Radiation Effects: ulcerogenic action, osteoporosis, reduce resistance to infections. The drug used for ulcerative colitis. In actuated to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. Forms chelates with Cu, Hg, Pb. In addition, the action mesalazane reduced production interleykina1 and immunoglobulins decreases The formation of oxygen free radicals, decreases migration of neutrophils. Mesalazane (salofalk) - 5aminosalitsilovaya Keep Vein Open Inhibits tsiklooksi-genazny and 5lipoksigenazny way to becoming arachidonic acid and thus violates the synthesis of prostaglandins and leukotrienes. The drug binds to the intracellular protein Human Herpesvirus in macrophages and neutrophils, disrupt microtubes and therefore reduces the migration of macrophages and neutrophils in the region deposits Organic Brain Syndrome uric Erythropoietin actuated their phagocytic activity and the allocation contradicts vovospalitelnogo glycoprotein. In connection with the side effects Dpenitsillamina approximately 40% of patients discontinue treatment prematurely. white female is prescribed inside.